Abstract: A parallel 6-DOF vibration isolation platform was built with piezoelectric ceramic actuators. And the NI Compact-RIO real-time control system and Fx-LMS adaptive filtering control algorithm were used for active vibration control. The secondary channel identification method and active control algorithm were simulated, and the active vibration control system was built for experimental verification. The simulation and experimental results show that the designed active vibration control system has a good control effect on the low-frequency micro-vibration at the range of 7 Hz to 50 Hz.