SYNTHESIS OF ~*I-IMP AS A BRAIN FUNCTIONAL RADIO IMAGING AGENT

ZHOU;YIGUO;JIN ZHONGPING;ZHU TONG;WANG QIONG;LIN XIANGTONG;LIU YONGCHANG Department of Radiopharmacy, School of Pharmacy, Shanghai Medical University Department of Isotope, Huashan Hospital, Shanghai Medical University

doi:10.7538/yzk.1987.21.02.0185

ZHOU;YIGUO;JIN ZHONGPING;ZHU TONG;WANG QIONG;LIN XIANGTONG;LIU YONGCHANG Department of Radiopharmacy, School of Pharmacy, Shanghai Medical University Department of Isotope, Huashan Hospital, Shanghai Medical University. SYNTHESIS OF ~*I-IMP AS A BRAIN FUNCTIONAL RADIO IMAGING AGENT[J]. Atomic Energy Science and Technology, 1987, 21(2): 185-185. DOI: 10.7538/yzk.1987.21.02.0185

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SYNTHESIS OF ~*I-IMP AS A BRAIN FUNCTIONAL RADIO IMAGING AGENT

ZHOU;YIGUO;JIN ZHONGPING;ZHU TONG;WANG QIONG;LIN XIANGTONG;LIU YONGCHANG Department of Radiopharmacy, School of Pharmacy, Shanghai Medical University Department of Isotope, Huashan Hospital, Shanghai Medical University

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~(125)I-labelled N-isopropyl-iodoamphetamine was synthesized and evaluated aspotential brain imaging agent. The synthesis of N-isopropyl-P-iodoamphetamineinvolves the following steps: acetylation, iodination, hydrolysis and alkylation.The ~(125)I-IMP labeled compound were prepared by adding Na~(125)I into the vialcontaining the ligand, Cu(II) nitrate and stannous chloride with greater than 95%radiochemical yield. The radiochemical purity of ~(125)I-IMP was checked by TLCwith two solvent systems and shown to be greater than 98%.

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SYNTHESIS OF ~*I-IMP AS A BRAIN FUNCTIONAL RADIO IMAGING AGENT

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