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Liu Guozheng Liu Fei Yang Ting Wang Yishan Miao Zengxing Fang Jidong (China Institute of Atomic Energy,P.O.Box 275 103, Beijing, 102413). STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA[J]. Atomic Energy Science and Technology, 1999, 33(6): 558-558. DOI: 10.7538/yzk.1999.33.06.0558
Citation: Liu Guozheng Liu Fei Yang Ting Wang Yishan Miao Zengxing Fang Jidong (China Institute of Atomic Energy,P.O.Box 275 103, Beijing, 102413). STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA[J]. Atomic Energy Science and Technology, 1999, 33(6): 558-558. DOI: 10.7538/yzk.1999.33.06.0558
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STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA

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  • The protonation constants of BPHA and its complexes of divalent metal ions Co 2+, Ni 2+, Cu 2+, and Zn 2+ are determined by potentiometric titration and non linear regression. The 1H NMR spectra of Zn 2+ BPHA at pD=2～12 is obtained on Varian 200. It proves that at pH≈6 the complex Zn(Ⅱ) H 2BPHA 2- loses a proton and a formerly free iminodiacetic acid moiety becomes coordinated; at pH≈9 the last proton is dissociated and an iminodiacetic acid moiety is released again. The 99 Tc m labelled product obtained at pH=7 is completely excreted through kidneys, different from the product forming at pH=4, which is taken up by liver considerably.
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