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TANG Jun;JIN Jian-nan;LIU Ning;LIAO Jia-li;YANG Yuan-you Key Laboratory for Radiation Physics and Technology of Education Ministry of China,Institute of Nuclear Science and Technology,Sichuan University,Chengdu 610064,China. Synthesis and Characterization of SPC as a Linker for Labeling Proteins With Astatine and Iodine Radioisotopes[J]. Atomic Energy Science and Technology, 2004, 38(3): 261-261. DOI: 10.7538/yzk.2004.38.03.0261
Citation: TANG Jun;JIN Jian-nan;LIU Ning;LIAO Jia-li;YANG Yuan-you Key Laboratory for Radiation Physics and Technology of Education Ministry of China,Institute of Nuclear Science and Technology,Sichuan University,Chengdu 610064,China. Synthesis and Characterization of SPC as a Linker for Labeling Proteins With Astatine and Iodine Radioisotopes[J]. Atomic Energy Science and Technology, 2004, 38(3): 261-261. DOI: 10.7538/yzk.2004.38.03.0261
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  • N-succinimidyl 5--(tributylstannyl)-3-pyridinecarboxylate (SPC), a useful linker forlabeling proteins with astatine and iodine radioisotopes, is synthesized in three steps with 5-bromonicotinic acid as a starting material, and is characterized by nuclear magnetic resonance(NMR), mass spectrometer(MS) and high performance liquid chromatography (HPLC). Withthis bi-functional ester, ~(125)I labeled human IgG is performed in labeling yield of approximately30%. Also, the in vitro stability of the prepared ~(125)I-IgG is evaluated.
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