Basic Experimental Study on Boron Neutron Capture Therapy

α particles and ⁷ Li ions are produced by radionuclide ²⁴¹Am and the HI-13 tandem accelerator respectively to simulate productions of BNCT(Boron Neutron Capture Therapy). DNA solution is irradiated by the above rays in air firstly, and then the DNA fragments are analized by AFM(Atomic Force Microscopy). The software ImageJ is used to measure the length of DNA fragments. Lastly, the experimental data of DNA fragments and DNA configuration are obtained. The results show that the mean length of DNA fragments increase as dose decreases; the fraction of linear and open circle DNA molecules increase as dose decreases; lithium particles cause strong relative biological effects than α particles.