Influence of Chelating Agents on Bio-distribution of Uranium in Mice

DENG Bing; WANG He-yi; JIANG Shu-bin; WANG Wen-hua

doi:10.7538/yzk.2012.46.08.0912

Atomic Energy Science and Technology > 2012 > 46(8): 912-917. > DOI: 10.7538/yzk.2012.46.08.0912

DENG Bing, WANG He-yi, JIANG Shu-bin, WANG Wen-hua. Influence of Chelating Agents on Bio-distribution of Uranium in Mice[J]. Atomic Energy Science and Technology, 2012, 46(8): 912-917. DOI: 10.7538/yzk.2012.46.08.0912

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Influence of Chelating Agents on Bio-distribution of Uranium in Mice

China Academy of Engineering Physics, P. O. Box 919-215, Mianyang 621900, China

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Tissue distribution of UO₂²⁺ in mice was investigated with dose of 5 mgU/kg and different chelating agents. A thermodynamic equilibrium model, involved in major metal-ions, low molecular weight molecule ligands and chelating agents, was made to analyze the speciation of UO₂²⁺ in human fluid. Computer simulation indicates that UO₂²⁺ will easily exist as [(UO₂)₂(OH)DTPA]^2- species when the presence of DTPA and UO₂²⁺ in the blood of mice can be significantly removed out, but to some extent will damage kidneys and bones at same time. In contrast, ascorbic acid prevents ordinary metabolism of uranium in kidneys of mice, without any effect on removal of uranium, unfortunately, the complex compound of UO₂²⁺ ion with ascorbic acid is [(UO₂)₂(OH)Ascorbate]²⁺ which will affect UO₂²⁺ normal removal from kidneys. It can be concluded that NTA has a little effect on removal of uranium in tissues and organs of mice and promote the UO₂²⁺ and PO₄^3-ion from solid phase as (UO₂)₃(PO₄)₂·4H₂O which will deposit on the bone surface.
- UO₂²⁺,
- chelating agents,
- computer simulation,
- speciation

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