Antiblastic Effect of Porphyrin Labeled with ¹³¹I Combined with Photodynamic Therapy to Tumor

The porphyrins of TPPOH and TPPNH₂ were labeled with ¹³¹I to obtain ¹³¹I-TPPOH and ¹³¹I-TPPNH₂. The human hepatocellular carcinoma cell line SMMC-7721 bearing nude mice was developed. The labeled compounds were injected into tumors directly to investigate the antiblastic effect of porphyrin, ¹³¹I and photodynamic therapy (PDT) to tumor. ¹³¹I-TPPOH and ¹³¹I-TPPNH₂ still remain in tumors after 14 d post injection, and it shows that the two porphyrins have good affinity to tumors. By the function of β-ray and PDT, the two ¹³¹I labeled porphyrins show a very effective antiblastic effect to tumors. It is possible to develop a novel solid tumor therapy ligand combined “porphyrin+¹³¹I+PDT”.