Preparation and New Zealand Rabbit Fracture Imaging of ¹⁸F-NaF Injection

The accurate diagnosis of the minute fractures and healing caused by trauma or tumor bone metastasis is very important for the development of appropriate treatment. In order to investigate the efficiency of ¹⁸F-NaF PET imaging for fracture diagnosis, ¹⁸F-NaF injection was prepared, and the quality control and stability were studied. Self-controlled study between ¹⁸F-NaF PET imaging and ⁹⁹Tc^m-MDP SPECT imaging after two weeks of the establishment of New Zealand rabbit fracture model was carried out. The results show that the production of ¹⁸F-NaF is more than 37 GBq, all of the test results conform to the requirements of the quality control, and the test results are no significant changes under the conditions of 40 ℃ for 8 h and 30 ℃ for 10 h. The results of imaging show that the whole body skeleton is visible in both of ⁹⁹Tc^m-MDP SPECT and ¹⁸F-NaF PET imaging, and high radioactive uptakes can be detected in fracture position. But PET imaging can be performed after ¹⁸F-NaF injection for 30 min, and fracture is more clearly displayed than SPECT imaging, while SPECT imaging can be performed after ⁹⁹Tc^m-MDP injection for 2 h. The radioactive uptake ratio (T/NT) between the fractured and the contralateral normal bones of ¹⁸F-NaF PET imaging is significantly higher than that of ⁹⁹Tc^m-MDP imaging. This study indicates that ¹⁸F-NaF PET is superior to ⁹⁹Tc^m-MDP SPECT for fracture imaging.