Abstract: This is a review of the selection of nuclear reactions, preparation of targets, heatevolved in irradiation, yield of thick target, and radiochemical separation in thepreparation of radionuclides ~(56)Co, ~(57)Co, ~(88)Y, ~(109)Cd and ~(208)Po produced by 1.2 mand 1.5 m cyclotrons in Beijing, Shanghai and Lanzhou