STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA
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摘要: 测定了N,N′-二胺乙基丙二胺六乙酸(BPHA)的加质子常数和它的二价金属离子配合物的加质子常数,不同pD值下BPHA和Zn2+ -BPHA的1H NMR谱。pH≈6 时,BPHA二价金属离子配合物有一质子离去,并伴有重大的结构变化。pH= 7 时,99Tcm -BPHA 标记物的生物分布与pH= 4时99Tcm -BPHA标记物的生物分布不同。pH= 7 时,99Tcm -BPHA具有优良的肾排泄性质Abstract: The protonation constants of BPHA and its complexes of divalent metal ions Co 2+, Ni 2+, Cu 2+, and Zn 2+ are determined by potentiometric titration and non linear regression. The 1H NMR spectra of Zn 2+ BPHA at pD=2~12 is obtained on Varian 200. It proves that at pH≈6 the complex Zn(Ⅱ) H 2BPHA 2- loses a proton and a formerly free iminodiacetic acid moiety becomes coordinated; at pH≈9 the last proton is dissociated and an iminodiacetic acid moiety is released again. The 99 Tc m labelled product obtained at pH=7 is completely excreted through kidneys, different from the product forming at pH=4, which is taken up by liver considerably.
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