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BPHA二价金属离子配合物的结构与~(99)Tc~m-BPHA生物分布的关系

BPHA二价金属离子配合物的结构与~(99)Tc~m-BPHA生物分布的关系[J]. 原子能科学技术, 1999, 33(6): 558-558. DOI: 10.7538/yzk.1999.33.06.0558
引用本文: BPHA二价金属离子配合物的结构与~(99)Tc~m-BPHA生物分布的关系[J]. 原子能科学技术, 1999, 33(6): 558-558. DOI: 10.7538/yzk.1999.33.06.0558
Liu Guozheng Liu Fei Yang Ting Wang Yishan Miao Zengxing Fang Jidong (China Institute of Atomic Energy,P.O.Box 275 103, Beijing, 102413). STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA[J]. Atomic Energy Science and Technology, 1999, 33(6): 558-558. DOI: 10.7538/yzk.1999.33.06.0558
Citation: Liu Guozheng Liu Fei Yang Ting Wang Yishan Miao Zengxing Fang Jidong (China Institute of Atomic Energy,P.O.Box 275 103, Beijing, 102413). STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA[J]. Atomic Energy Science and Technology, 1999, 33(6): 558-558. DOI: 10.7538/yzk.1999.33.06.0558

BPHA二价金属离子配合物的结构与~(99)Tc~m-BPHA生物分布的关系

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  • 中图分类号: O614.712

STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA

  • 摘要: 测定了N,N′-二胺乙基丙二胺六乙酸(BPHA)的加质子常数和它的二价金属离子配合物的加质子常数,不同pD值下BPHA和Zn2+ -BPHA的1H NMR谱。pH≈6 时,BPHA二价金属离子配合物有一质子离去,并伴有重大的结构变化。pH= 7 时,99Tcm -BPHA 标记物的生物分布与pH= 4时99Tcm -BPHA标记物的生物分布不同。pH= 7 时,99Tcm -BPHA具有优良的肾排泄性质

     

    Abstract: The protonation constants of BPHA and its complexes of divalent metal ions Co 2+, Ni 2+, Cu 2+, and Zn 2+ are determined by potentiometric titration and non linear regression. The 1H NMR spectra of Zn 2+ BPHA at pD=2~12 is obtained on Varian 200. It proves that at pH≈6 the complex Zn(Ⅱ) H 2BPHA 2- loses a proton and a formerly free iminodiacetic acid moiety becomes coordinated; at pH≈9 the last proton is dissociated and an iminodiacetic acid moiety is released again. The 99 Tc m labelled product obtained at pH=7 is completely excreted through kidneys, different from the product forming at pH=4, which is taken up by liver considerably.

     

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  • 期刊类型引用(1)

    1. 黎磊磊,刘茂龙,倪嵩,王小文,刘利民,顾汉洋. 湿空气在全尺寸压水堆燃料组件中的自然循环特性试验及理论研究. 核技术. 2024(08): 159-168 . 百度学术

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出版历程
  • 收稿日期:  1998-11-27
  • 刊出日期:  1999-11-19

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