STRUCTURES OF M 2+ BPHA COMPLEXES AND THEIR RELATIONSHIP TO THE BIODISTRIBUTION OF ~(99) Tc m BPHA
-
摘要: 测定了Ｎ，Ｎ′－二胺乙基丙二胺六乙酸（ＢＰＨＡ）的加质子常数和它的二价金属离子配合物的加质子常数，不同ｐＤ值下ＢＰＨＡ和Ｚｎ２＋ －ＢＰＨＡ的１Ｈ ＮＭＲ谱。ｐＨ≈６ 时，ＢＰＨＡ二价金属离子配合物有一质子离去，并伴有重大的结构变化。ｐＨ＝ ７ 时，９９Ｔｃｍ －ＢＰＨＡ 标记物的生物分布与ｐＨ＝ ４时９９Ｔｃｍ －ＢＰＨＡ标记物的生物分布不同。ｐＨ＝ ７ 时，９９Ｔｃｍ －ＢＰＨＡ具有优良的肾排泄性质Abstract: The protonation constants of BPHA and its complexes of divalent metal ions Co 2+, Ni 2+, Cu 2+, and Zn 2+ are determined by potentiometric titration and non linear regression. The 1H NMR spectra of Zn 2+ BPHA at pD=2～12 is obtained on Varian 200. It proves that at pH≈6 the complex Zn(Ⅱ) H 2BPHA 2- loses a proton and a formerly free iminodiacetic acid moiety becomes coordinated; at pH≈9 the last proton is dissociated and an iminodiacetic acid moiety is released again. The 99 Tc m labelled product obtained at pH=7 is completely excreted through kidneys, different from the product forming at pH=4, which is taken up by liver considerably.
-
-
[1] 1 Liu GZ, Liu BL. Synthesis ofa New Polyam inopolycarboxylic Acid(BPHA) and Its Labeling With 99Tc.JLabelled Com pd Radiopharm, 1998, 41(2): 972 赵春雷,李亚明,栗维国,等. 99Tcm -DTPA在细菌性浓肿中的浓聚和显像. 同位素,1997,10(1):513 Jurisson S, Bering D,WeiJ, et al. Coordination Com pounds in NuclearMedicine. Chem Rev, 1992, 93:11374 Sandoval AA, Sandoval MW, Lin E, et al. Hydrogen Bonding in Som e Polyam inocarboxylic Acids. JMag Reson, 1970, 3: 2585 Sm ith BB, Betts RH. Structure and Sterochem istry of a Cobalt(Ⅲ)-diethylenetri-am inepentaacetic AcidCom plex. JAm Chem Soc, 1969, 91(27):77496 PetersAM, Myers MJ, Moham m adtaghiS, etal. BidirectionalTransportofIm inodiaceticOrganicAnionAnalogues Betw een Plasm a and Hepatocyte. Eur JNuclMed, 1998, 25(7):766 -
期刊类型引用(1)
1. 黎磊磊，刘茂龙，倪嵩，王小文，刘利民，顾汉洋. 湿空气在全尺寸压水堆燃料组件中的自然循环特性试验及理论研究. 核技术. 2024(08): 159-168 . 
百度学术
其他类型引用(3)
计量
- 文章访问数: 530
- HTML全文浏览量: 0
- PDF下载量: 1080
- 被引次数: 4
下载:
