Abstract: To study engineering application of quick displacement of hydrogen isotopes and search the hydrides that are able to implement quick displacement, a series of one-dimensional displacement experiments between hydrogen and deuterium in metal hydride columns packed with ZrCo,LaNi5, LaNi4. 7 A10.3 and Pd, respectively are carried out. Results indicate that displacement characteristics relate to factors such as temperature, rate of gas flow, specific surface area of solid phase and hydrogen isotope separation factor of the metal-hydrogen system. At room temperature, the palladium hydride possesses with the quickest displacement rate, and the next are LaNi5, LaNi4.7 A10.3 and ZrCo in turn. The preliminary analysis shows that the rule of the exchange reaction of hydrogen isotopes in gas-solid interface determines the displacement behavior. Using Pd as packing material,the engineering applications of quick displacement may well be achieved.