Abstract: In order to improve safety, economy and reliability of operation for nuclear power plant(NPP), a novel integrated managing method was proposed based on the ideas of computer and contemporary integrated manufacturing system (CIMS). The application of CIMS to nuclear power plant safety management was researched. In order to design an integrated managing system to meet the needs of NPP safety management, all work related to nuclear safety is divided into different category according to its characters. On basis of this work, general integrated managing system was designed at first. Then subsystems were designed and every subsystem implements a category of nuclear safety management work. All subsystems are independent relatively on the one hand and are interrelated on other hand by global information system.