Abstract: Zr and stainless steel(S.S.) was selected respectively as the cladding materials of W target. The electric beam weld was used to prepare the W-Zr and W-S.S. small samples for HIP. The technology parameters of HIP were investigated at 1200,1300,1400℃and 180Mpa, respectively. The micro-morphology of interface, diffusion depths and composition as well as their micro-hardness were observed and determined. The results indicate that the uniting of W-Zr and W-S.S is very well under the testing conditions, there is no any space or micro-crack in the interface, there is no grain growth of W either. The diffusion of Zr to W at the interface of W-Zr is preference during HIP process, the diffusion depths under testing conditions are 6-9μm; The diffusion of W and Fe is considerable at the interface of W-S.S., its depth is about 13μm, but the diffusion of Cr and Ni is a little; The hardness at the interface of W-Zr and W-S.S. shows that there is a diffusion layer at the interface of W-Zr, and W-S.S., respectively; A part of stainless steel cladding was melted after HIP at 1300℃ and 180Mpa, therefore, 1200℃ and 180MPa is suitable conditions of HIP for W-S.S., but 1300℃ and 180MPa is better for W-Zr.