Abstract: COUPLE which couples MCNP and ORIGEN2 is applied to the neutron simulation and burn-up calculation for accelerator driven sub-critical system (ADS) sodium cooled fast reactor loaded with metallic fuel. Minor actinide (MA) transmutation effect and reactivity parameters of MAs homogeneous and heterogeneous cores were investigated. The result shows that, compared with homogeneous core, heterogeneous core achieves a higher MAs transmutation ratio and support ratio. Some safety parameters deteriorate, such as lower Doppler effect, lower delayed neutron effectiveness and higher sodium void effect. The power distribution and accelerator beam power do not vary obviously.