Abstract: he technology of nuclear energy seawater desalination was discussed in the paper. The different interfaces of nuclear power applied in desalination technology were also analyzed. Because of good performance, low energy wastage and other reasons, the horizontal tube and low temperature MED (LT-MED) technology is very coupling with nuclear heating reactor (NHR).Then, the principle and application of LT-MED technology were introduced. In the end, a physicalmathematical LT-MED model was developed to explore the thermal hydraulic performance. Two temperature difference distribution schemes, equal temperature difference and equal heat transfer area temperature difference, were analyzed for the system design.