Abstract: On the basis of nuclear power plant (NPP) best-estimate transient analysis code RELAP5/MOD3, the point reactor kinetics model in RELAP5/MOD3 was replaced by the two-group, 3-D space and time dependent neutron kinetic model, in order to exactly analyze the responses of key parameters in natural circulation and its transition process considering the reactivity feedback. The coupled model for three-dimensional physics and thermohydraulics was established and corresponding computing code was developed. Using developed code, natural circulation of NPP and its transiton process were calculated and analyzed. Compared with the experiment data, the calculated results show that its high precise avoids the shortage that the point reactor equation can’t reflect the reactivity exactly. This code can be a computing and analysis tool for forced circulation and natural circulation and their transitions.