Abstract: The control structure of EPICS and PLC is used in the cryogenic and superconductive control system of Beijing Electron Positron Collider (BEPCⅡ), which solves the problem that a pure PLC control system does not allow the user to modify the industrial flow on-line. It is convenient to modify control flow and improve control logic on-line according to users’ requirement in the EPICS-PLC system. The system architecture, functionality, interlock and flow control are described.