Abstract: New fuel assembly loading machine of China Experiment Fast Reactor is a kind of kinetic equipment with very complex structure. Many of its motional and driving components can not be simulated exactly by finite element model (FEM). A simplified FEM analysis method was introduced in the paper, and the main frame of the equipment was simulated by a simplified FEM model. Response spectrum analysis method was used to obtain the acceleration response of the main components of the equipment under seismic condition. Theoretical analysis method was used to calculate the stresses of the main connecting bolts, and these bolts were evaluated based the regulations of nuclear codes to ensure the structure integrity of the equipment.