Abstract: Yemaquan region in Beishan area, Gansu Province, is one of the preselected sites of disposal repository for high-level radioactive waste (HLW) in our country. The main content of natural analogue research of high-level waste disposal repository was introduced in the paper. The major geochemical issues related to the analogue research were described. Taking Yemaquan rock body as an example, U, Th, radioactive features and U isotopes of groundwater were studied. The result shows that the migration ability and distance of U are very limited in the geological, hydrogeological environmental conditions. This cognition provides very important information and basis for the evaluation of Yemaquan preselected site.