Abstract: Based on detailed analysis of the structure and key techniques of a virtual reality system, the applications of virtual reality to simulation in nuclear power plant (NPP) were developed. In order to meet the requirement of simulation in NPP, motion simulation of control rod drive system, walking system inside the containment and virtual main control room were presented. A simulator of NPP was connected to interchange dynamic data between virtual main control room and the simulator. The simulating results show that the technique of virtual reality can be applied well to the simulation inside containment, which is filled with activity material, and the simulation of virtual main control room, where human factors must be considered. It also can be used well to design virtual education and training system of NPP.