Abstract: In order to verify the utilization of low enrichment uranium (LEU) in accelerator driven sub-critical system (ADS), the IAEA benchmark facility IPEN-MB-01 was introduced. The MCNP code was used to simulate and calculate the parameters of sub-critical configuration of IPEN-MB-01. The keff and ks, neutron flux distribution, neutron energy spectrum of the facility which is driven by D-D or D-T external source were researched. The calculation method of parameters was explained. The comparison of data from different countries was performed.