Abstract: By coincidence method, the calibrationn technique of ZnO：Ga crystal response to single heavy charged particle was established, the waveform response to the single alpha particle was measured, the experiments data were analysed, and the time response to single proton was gained from the plasma time relationship. The results show that the rise time is 324 ps and the FWHM is 686 ps. The ZnO:Ga crystal has a good response to heavy charged particles. It is possible to develop an efficient alpha particle detector for use in a deuterium tritium neutron generator and other new radiation technology.