Abstract: The phenomena of fluid-structure interaction exist widely in nuclear power plants. Structural dynamic problems caused by those phenomena have important influence on the structure integrity and safety of nuclear power plants, which attract more and more attentions on this aspect at home and abroad now. North China Electric Power University (NCEPU) has been doing some related researches. The paper introduces some researches, such as a new method to calculate the added mass for the seismic analysis of the fuel assembly in fast breeder reactor (FBR), simulation on the vortex shedding of double heat exchange tubes in a steam generator, simulation on the vortex shedding caused by the cross -flow over plates in a fuel assembly of an advanced reactor, the research on the impacting phenomenon of the free-surface on the vessel head in a storage tank as the main vessel of the China Experimental Fast Reactor (CEFR) shaken by the earthquake, and the researches on the solution of the liquid sloshing by moving particle semi-implicit (MPS) and the scattering phenomenon caused by sloshing, and so on.