Abstract: A series of low cycle fatigue tests were carried out on small funnel-like slice-specimens of Zr-Sn-Nb alloy at room temperature and 500 ℃. Based on the local uniaxial strain of small funnel-like specimens, the fatigue damage equivalent hypothesis was given. Through finite element analysis, the strain conversion model for funnel-like specimens from uniaxial testing strain to local uniaxial strain was established, besides, the validity of finite element analysis was checked by the test results; with the results of test, Manson-Conffin model for Zr-Sn-Nb alloy strain fatigue life estimation was presented. The results show that, Zr-Sn-Nb alloy exhibites cyclic stability; elevated temperature shorten the fatigue life of Zr-Sn-Nb alloy seriously and temperature effect impairs gradully with the increase of strain amplitude.