Abstract: A model for predicting single-phase flow resistance in channel filled with particles was developed by using Fluent6.3 software. It is showed that the predictions agree well with the experimental data for nondimensional D=0.16, 0.1 and 0.04; flow resistance increases with decrease of non-dimension diameter D; the pressure drop of single-phase in porous media channel can not be well predicted by existing models, from which the numerical results are considerably influenced by the selected methods for calculating the drag coefficient C_F in these models.