Abstract: The contents of main elements, Si, Al, Fe and Ca in cement raw meal were determined by prompt γ neutron activation analysis (PGNAA) with a D-D neutron generator as neutron source. Characteristic γ-rays of the elements were emitted when a sample was irradiated by neutron. Characteristic γ-rays of corresponding elements for cement raw meal were quantitatively analyzed by measuring the energy and the intensities. The results have good repeatability and the standard deviation is well within the allowable range. Compared with chemical method, PGNAA method can meet the demand of industrial production because of its short testing time, non-destruction, high accuracy, high precision and the ability to measure many elements simultaneously.