Abstract: The relationship between probabilistic safety assessment (PSA) and severe accident study was discussed. Also how to apply PSA in severe accident prevention and mitigation was elaborated. PSA can find the plant vulnerabilities of severe accidents prevention and mitigation. Some modifications or improvements focusing on these vulnerabilities can be put forward. PSA also can assess the efficient of these actions for decision-making. According to CPR1000 unit severe accident analysis, an example for the process and method on how to use PSA to enhance the ability to deal with severe accident prevention and mitigation was set forth.