Abstract: In order to further reduce the misoperation after the faults occurring of nuclear power plant, according to the function distribution of nuclear power equipment and the distributed control features of digital instrument control system, a nuclear power plant distributed condition monitoring and fault diagnosis system was researched and designed. Based on decomposition-integrated diagnostic thinking, a fuzzy neural network and RBF neural network was presented to do the distributed local diagnosis and multi-source information fusion technology for the global integrated diagnosis. Simulation results show that the developed distributed status monitoring and fault diagnosis system can diagnose more typical accidents of PWR to provide effective diagnosis and operation information.