Abstract: The spallation target is located in the center of an accelerator driven sub-critical system (ADS), which produces neutron source for nuclear transmutation. Based on the analysis of the thermal-hydraulic demands for spallation target, lead-bismuth eutectic (LBE) was chosen as the spallation target and the coolant for the ADS. MCNP code was used to calculate the deposition heat in the spallation target, and the CFD code FLUENT was employed to calculate the thermal-hydraulic behavior in the spallation target zone. Different design parameters as well as different window shapes were analyzed in order to find their effects to the temperature distribution and velocity distribution, and the suitable design options were found to meet the thermal-hydraulic requirements.