Abstract: The paper introduced the development and process of CN-101 ⁶⁰Co sealed source for industrial irradiation, including the structure design, prototype test, under-water disassembly of cobalt bundles, underwater activity measurement of cobalt rods, cutting of cobalt rods, encapsulation and welding of capsules, leakage test, surface contamination test, outside dimension measurement, and activity measurement of the finished sources. The products passed through certification test in February 2011, and the results show that all technical parameters reach the advanced world level. The successful development of CN-101 sealed source fills the vacancy of domestic fields and breaks with the monopoly of foreign products. Annual fabrication capacity can reach to 2.035×10¹⁷ Bq.