Abstract: In order to determine the extent to which the licensing basis remains valid and the extent to which the reactor conforms to current safety standards and practices, referring to the current nuclear safety regulations and guides, the review was performed to the second period safety review (PSR) of HFETR from 2009 to 2011. The focus of the review is actual condition, safety analysis, safety performance and ageing. The inspection and assessment conclusions of the influences for 5.12 Wenchuan Earthquake on HFETR in review were considered. The inspection and analysis results of HFETR current actual condition and safety status show that the three safety functions of HFETR including safe shutdown, cooling and constrain of radiation release are ensured, by means of a series of renovation, modification, testing and maintenance for many years.