Abstract: Vanadium alloy has become an important structural material for its good strength at elevated temperature, low irradiation activity and irradiation swelling resistance. For evaluating the deformation and damage evolution in V-5Cr-5Ti alloy under stress state, the tension test and numerical simulation for V-5Cr-5Ti alloy specimens with smooth and notch were developed, and the fracture planes were observed by SEM. The parameters in the constitution law for vanadium alloy were deduced from the experiment. The stress and strain distributions and the damage evolution in the specimens were simulated numerically during tension loading. Comparing the loading displacement curve from simulation with that from experiment, it is shown that they are very identical in the state of elastic and plastic deformation, so the finite element model and the parameters in the constitution law and damage model are verified. The static tension fracture mechanisms for the smooth and notch specimens were obtained by SEM.