Abstract: Experimental research under supercritical pressure conditions was carried out on heat transfer performance in vertical tube of 10 mm with a wide range of experimental parameters. The impacts of heat flux, mass flow rate and pressure on wall temperature and heat transfer coefficient were investigated. The experimental parameters are following: The pressures are 23, 25, 26 MPa, the mass flow rate range is 450-1200 kg/（m²•s）, and the heat flux range is 200-1200 kW/m². Experimental results indicate that the wall temperature gradually increases with the bulk temperature, and heat transfer enhancement exists near the critical temperature as the drastic changes in physical properties. The increase in heat flux and the decrease in mass flow rate reduce heat transfer enhancement and lead to deterioration of heat transfer. The main effects of pressure are reflected in the difference of heat flux and bulk temperature of the start point where heat transfer deterioration and enhancement occur.