Abstract: A low temperature nuclear heating reactor (NHR) power plant is needed to provide all the resources including desalted water, heat and industrial steam, and part of electricity if a city near the sea is far away from fresh water supply network, power grid and heating network. The goal is to obtain the best economic benefits and to achieve the optimal economic operation under the precondition of ensuring the safety of low temperature nuclear heating reactor. In this paper, an open-loop optimization method was used to study the steady-state operation target of NHR under the load following operation mode, and to provide input parameters for the design analysis of NHR load following control system.