Abstract: The fuel management of the PWR reactor core reload optimization was studied with SCIENCE codes in the paper, the PWR core consists of 157 fuel assemblies. The paper studied five strategies, three strategies are one-year reload and the other two are 18-month reload strategies. The main results of the eight cycles for the five strategies were given, and the results were compared with each other. In conclusion, the power peak of the OUT-IN strategy loading pattern is lower, and the power peak of the IN-OUT loading pattern is higher, but all of them are satisfied with design limitation. The average discharge burnup of the quarter core strategy is the highest, which means that the assemblies of this strategy are burned the most sufficiently, so the economic efficiency of the quarter core strategy is the best.