Abstract: During the 5th refueling outage of Tianwan Nuclear Power Station Unit 1, according to the fuel assembly inspection results, emergency refueling design has been carried out. The in-core loading scheme of Unit 1 Cycle 6 has special characteristics from normal refueling. For example, fuel loading is asymmetry, some burned fuel assemblies are moved to symmetrical sectors, and in-core power distribution is asymmetry etc. In addition, in-core loading scheme has been considered the requirement on positions of TVS-2M pilot fuel assemblies. Verified by physics tests and in-core measurement system at beginning of cycle 6, design results of in-core loading pattern meet all measurement criteria and requirements, and in-core operation conditions conform to design anticipate.