Abstract: The multilevel flow model (MFM) and the signed directed graph (SDG) were combined to analyze the alarm signals of the secondary loop system for nuclear power plant. The MFM was used to delaminate and describe nuclear power plant, and the SDG was used to analyze the logicality of the facility sign in the MFM. Two kinds of faults in the secondary loop system in nuclear power plant were simulated and the alarm signals were analyzed. The simulation results show that the fault source can be identified exactly and the transmit route of the alarm signals can be described clearly, which is helpful for operators to judge.