Abstract: Achieving exactly quantitative holdup in uranium produced tank is a key point for nuclear material account and control. Due to the tank’s particularity design and gamma ray remarkable self-absorption, conventional calibration methods can’t be adopted for self-absorption data analysis. The self-absorption correction method in the special case was researched, and also a two-dimensional model for self-absorption correction was established. It is available for these cases such as thickness of the material, matrix ingredients and geometric are incomprehensive. The validation of simulation sample shows that the two-dimensional model meets the requirement of holdup measurement in uranium produced tank.