Abstract: A silver mediated electrochemical oxidation is a promising technique for the destruction of organic compounds. The destruction of spent organic solvent in nitric acid medium containing Ag⁺ was studied by using a laboratory scale electrochemical oxidation cell and fresh 30% tri-isoamyl phosphate (TiAP). The factors affecting the generation of Ag²⁺ and its capability to decompose TiAP were investigated, which include temperature, nitric acid concentration and current density. The results show that the generation of Ag²⁺ increases with the concentrations of HNO₃ and Ag⁺ and reduces with the increase of temperature. It is also found that the destruction rate of TiAP is 99.9% with a temperature of 40 ℃, a nitric acid concentration of 8 mol/L, and a current density of 0.5 A/cm² for 8 h.