Abstract: The comparison and analysis for the requirements of airborne radioactive material sampling and monitoring in ISO 2889—2010 and ANSI N13.1—1999 were carried out. Combined with the domestic nuclear power plant chimney airborne radioactive material sampling and monitoring of the status-quo, difficulties in implementation of the new standard were discussed. Some concerns for chimney airborne radioactive material sampling and monitoring design in the application of new standards were given.