Abstract: Taking the steam generator of Daya Bay Nuclear Power Station as the research object, one-dimensional dynamic model of the steam generator based on drift flux theory and leak model of heat transfer tube were established. Steady simulation of steam generator under different conditions was carried out. Based on verifying the drift flux model and leak model of heat transfer tube, the effect of leak location and flow rate under different conditions on steam generator’s key parameters was studied. The results show that the drift flux model and leak model can reflect the law of key parameter change accurately such as vapor mass fraction and steam pressure under different leak cases. The variation of the parameters is most apparent when the leak is at the entrance of boiling section and vapor mass fraction varies from 0.261 to 0.163 when leakage accounts for 5% of coolant flow rate. The successful prediction of the effect of heat transfer tube leak on dynamic characteristics of the steam generator based on drift flux theory supplies some references for monitoring and taking precautionary measures to prevent heat transfer tube leak accident.