Abstract: In order to calculate the local pressure loss coefficient for flow distribution baffle and cross flow in steam generator, a three-dimensional static thermal-hydraulic software GENEPI was used. The flow field between the inlet of tube-bundle region and downstream of the second tube support plate was modeled, under the single phase flow condition without calculating the gravity. The static pressure of inlet was calculated, which can deduce the pressure drop between the inlet and outlet. Then by subtracting the pressure loss of tube support plates and fictional resistance, the pressure loss coefficient for flow distribution baffle and cross flow can be calculated. In order to verify the correctness and feasibility of the method, the local pressure loss coefficients of CPR1000-SG and EPR-SG were calculated. The results were compared with foreign empirical coefficients, which shows that results are very close and the error is accepted.