Abstract: A three-dimensional steady state analysis software GENEPI was used to do the thermal-hydraulic analysis of tube bundle region for secondary side of CPR1000 steam generator. The porous medium model and local pressure-drop model were used in GENEPI to represent the tubes and pressure-drop of the complex geometry. The flow and temperature fields of the tube bundle in secondary side were analyzed and the highest steam quality in the tube bundle is 0.3. The kinetic energy of typical tubes was acquired by a computer code as the input for the flow-induced vibration analysis. The result shows that the flow induced vibration in heat transfer tubes is acceptable. At the same time, the flow and temperature fields near the tube sheet were analyzed and the fouling deposit region was predicted based on such a model and working condition. The result can be used as the input for the design of draining pipe. The calculation results verify the rationality for the design of the CPR1000 steam generator secondary side tube bundle region.