Abstract: The experimental research of compaction dealing with the radioactive solid waste and the influence factors of the different materials during the compression process were discussed. The results show that the material treatment range of high pressure compression is wide and the requirements of classification are not strict. According to the different characteristics and loading densities, the volume reduction ratio is 2.3-11 and the average density of materials is 1200-3900 kg/m³ when the pressure is 600 kN. The average densities of the soft materials, hard materials with holes and elastic materials are greater than their matter densities. After compaction, the average densities of materials with different loading densities are basically same. The volume reduction ratio is related to the materials’ own properties and loading density. The elastic materials rebound significantly and break pellets after compaction, and other materials rebound rates are less than 20%.