Abstract: A set of large pumping speed tailored cryopanel exhaust system placed in CYCIAE-100 compact cyclotron magnet valley area was designed for high vacuum requirement, which makes pressure in the main tank better than 5×10^-6 Pa. The Monte-Carlo method was used to optimize the designed structure based on the characteristics of magnet valley area. The machining and commission of cryopanel exhaust system has been done. After the first commission, the temperature on cryopanel reaches 19 K, and the pressure in CYCIAE-100 compact cyclotron main tank reaches 8×10^-6 Pa.