Abstract: The effective delayed neutron fraction (β_eff), mean neutron generation time (Λ) and reactivity feedback coefficient (α) are the most important parameters in nuclear reactor kinetics. In this study, Monte Carlo method was applied to calculate the kinetic parameters of accelerator driven sub-critical system (ADS) cores, and the effect of minor actinides (MA) content on these parameters was analyzed. The different contents of MA in the fuel were investigated to determine its effect on the kinetic parameters. The results show that when the content of MA reaches 5% in the fuel, the β_eff and Λ decrease by about 18% and 31%, respectively. With the increase of MA content from 0% to 5%, the average value of Doppler feedback coefficient α^-D varies from -0.56 pcm/K to -0.36 pcm/K, and the average value of coolant feedback coefficient α^-C varies from -2.11 pcm/K to -1.73 pcm/K.