Abstract: Taking the epoxy resin as the research object in this paper, shielding property of epoxy resin was analyzed in the energy of 0.001-100 MeV, and shielding test was carried by ⁶⁰Co gamma ray. Besides, the irradiation for epoxy resin was treated by 93.5 kGy gamma ray, while the density, macro photograph, mechanical property, micro morphology, temperature resistance and infrared spectra of epoxy resin before and after irradiation were analyzed. The results show that the attenuation of the gamma ray by epoxy resin is mainly related to the photoelectric absorption in the low energy (E<0.01 MeV), is mainly related to the incoherent scattering in the intermediate energy (0.01 MeV<E<10 MeV), is mainly related to the incoherent scattering and pair production in nuclear field in the high energy (10 MeV<E<100 MeV), and the shielding property of epoxy resin by ⁶⁰Co gamma ray is general. The irradiation of 93.5 kGy gamma ray results in the aging phenomenon of epoxy resin, the decrease of density and the highest heat resistant temperature, the increase of mechanical property and the lowness of destruction level, which shows the irradiation resistance of epoxy resin for 93.5 kGy gamma ray.