Abstract: The systemic application of probabilistic safety assessment (PSA) method to radiation risk assessment of radioactive material transportation was explored, and then the radiation risk of road transportation of new fuel elements of HTR-PM was analyzed. Based on actual route data and potential accident scenarios, both accident conditions of package radiation level hoist and criticality were chosen for accident frequency analysis. The results show that the frequency of package radiation level hoist accident is 4.21×10^-7 (vehicle•each transportation)^-1, while the consequence of criticality accident could not be considered because its frequency is less than 1×10^-13 (vehicle•each transportation)^-1. The results of accident consequence show that in the package radiation level hoist accident, the maximum external exposure dose arising from the accident for emergency worker is 0.55 mSv, and 4.55×10^-3 mSv for public people around, which are acceptable. The global radiation risk is 1.24×10^-10 person•Sv/(vehicle•each transportation), for which impact accident contributes the maximum percent.