Abstract: The range of alternating stress usually exceeds the yield limits for some serious transits with high variation of temperature and pressure in nuclear equipment, where the simplified elastic-plastic fatigue analysis usually could not satisfy the requirement of ASME code. In the paper, the strain-based plastic fatigue analysis was studied to reduce the conservativeness of the simplified elastic-plastic fatigue analysis, and the plastic fatigue analysis of feeding tube connection in steam generator was studied. The results show that the plastic fatigue analysis successfully decreases the redundancy of elastic plastic fatigue analysis. This paper provides a good way to the fatigue issue with severe transit in engineering practice.