Abstract: In the event of a serious accident in the nuclear power plant, the atmospheric diffusion model is needed to evaluate the environmental consequences of nuclear accidents, and the accuracy of the model can be verified by wind tunnel experiment. In order to improve the accuracy of the verification for the wind tunnel experiment, the multi-fan technology in the structural wind resistance, which overcomes the shortcomings of the traditional passive wind tunnel such as the poor adaptability to the boundary layer simulation and the complicated regulation, was put into the simulation of the atmospheric diffusion of the nuclear accident. Through the design of 10 (row)×8 (column) multi-fan wind tunnel and the build of an active control system with wind speed feedback for fan array, the simulation of wind speed profile of boundary layer at class D stability was carried out by this multi-fan wind tunnel. The rapid simulation of the wind speed profile of the Shidaowan Nuclear Power Plant site was realized in this paper, and the simulation precision is relatively high. The reliability of the simulation for the atmospheric boundary layer is verified with the multi-fan wind tunnel technology, which provides a new empirical method for the experiment of atmospheric diffusion wind tunnel.